Phenotype Accessibility and Noise in Random Threshold Gene Regulatory Networks
نویسندگان
چکیده
منابع مشابه
Phenotype Accessibility and Noise in Random Threshold Gene Regulatory Networks
Evolution requires phenotypic variation in a population of organisms for selection to function. Gene regulatory processes involved in organismal development affect the phenotypic diversity of organisms. Since only a fraction of all possible phenotypes are predicted to be accessed by the end of development, organisms may evolve strategies to use environmental cues and noise-like fluctuations to ...
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Proteins are the functional machinery in living cells. Proteins interact with each other and bind to DNA to form so-called gene regulatory networks and in this way regulate the level, location and timing of expression of other proteins. Cells implement feedback loops to create a memory of their gene expression states. In this way, every differentiated cell in a multicellular organism remembers ...
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MOTIVATION A basic issue for translational genomics is to model gene interaction via gene regulatory networks (GRNs) and thereby provide an informatics environment to study the effects of intervention (say, via drugs) and to derive effective intervention strategies. Taking the view that the phenotype is characterized by the long-run behavior (steady-state distribution) of the network, we desire...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0119972